Carblinazole is an ant/thyroid drug used in treatment of hyperthyroidism.
The use of Carbimawle was associated with various adverse effects in male
reproductive system.
Spermatogenesis is an extremely active process with high rate of cell division
that leads to high rates of mitochondrial oxygen consumption by the
germinal epithelium. However, oxygen tensions in this tissue are low so both
spermatogenesis and Leydig cell steroidogenesis are vulnerable to oxidative
stress.
Testes and epithdymes contain high concentrations of Selenium indicating
its vital role during spermatogenesis to improve semen quality. This
study was designed to evaluate the effect of Carbirnazole on testicular activity
in albino rats and the ameliorative role of selenium.
The rats in this study were divided into 4 groups. Group (1) that were
served as normal control, Group (2) were orally even Carbimazole Group (3)
were orally given sodium selenite and Group (4) that were orally administered
Carbimawle and sodium selenite for 8 weeks. Testicular reduced glutathione
concentration (GSH), Testicular malondialdehyde (AIDA) concentrations,
Epididymal sperm count. Sperm motility. Sperm abnormalities, serum
testosterone, LH, FSH levels and testicular histopathology were examined.
we can conclude that, treating animals with selenium causes improvement
in normal testicular function of rats. In addition combination of selenium
with Carbimazole showed improvement in testicular alterations induced by
Carbirnazole in rats |
