The discovery of the f-channel and its role in regulating pacemaker activity
lead to the development of new pharmacological agents such as ivabradine, which
target these f-channels causing a reduction in heart rate by inhibiting the If current
The aim of the present work was designed to evaluate the cardioprotective
effect of ivabradine on experimentally- induced myocardial infarction and adrenalineinduced
arrhythmia in rats. In addition, the present work studied the effect of
ivabradine on isolated rabbit's aortic spiral strip and isolated rabbit's heart.
Acute myocardial infarction in rats was induced by isoperameline (150mg/kg
subcutenous injection, once) 24 rats were divided into the following groups: group (1)
control normal rats, group (II) myocardial infarction — induced rats with no previous
treatment, group (III) myocardial infarction — induced rats pretreated with ivabradine
(I0mg/kg/day) for one week and group (IF)) myocardial infarction — induced rats
pretreated with carvedilol (1 mg/kg/day) for one week Electrophysiological,
biochemical and histopathological parameters were estimated pretreatment with
either ivabradine or carvedilol show significant improvement in all these parameters
with insignificant difference between them.
In the current work 20 rats were used to investigate the protective effects of
ivabradine (I0mg/kg) and carvedilol (lmg/kg) on adrenaline- induced arrhythmia in
anaesthetized rats and the results revealed that both drugs had a prophylactive effect
Also data obtained in the present work pointed out that ivabradine in
gradually increasing doses produce no significant effect on the isolated rabbit's aortic
strip and basal myocardial contractility of isolated rabbit's heart.
Both ivabradine and carvedilol have cardioprotective effect against acute MI
as well as adrenaline- induced arrhythmia with no significant difference between
them, also ivabradine has no effect on contractility of the heart So, • the choice of
either drug in these disease states depend on which of them has low side effects. |
