Valsartan is a member of angiotensin type 1
receptor antagonists. The present study was
carried out to screen the pharmacological effects
of valsartan on isolated rabbit aortic strip and
isolated rabbit heart. Also, the effect of
valsartan on mean arterial blood pressure response
to angiotensin(Ang) II injection was evaluated.
Moreover, the cardio-protective effect of
valsartan on acute myocardial infarction induced
experimentally in rats was studied. Data obtained
in the present study pointed out that valsartan
produced significant decrease (P<0.05) in the Ang
II induced contraction of isolated rabbit aortic
strip but did not affect norepinephrine induced
contraction in the isolated rabbit aortic strip.
Also , valsartan in gradually increasing doses
produced no effect on amplitude of contractility of isolated rabbit heart ,but significantly
reduced the positive inotropic action of Ang II on
isolated rabbit heart. Moreover, valsartan
inhibited the pressor response to Ang II ir vivo
as it lowers the elevated blood pressure induced
by Ang II injection.Also, valsartan has cardioprotective
effect on experimentally induced
myocardial infarction induced by isoprenaline in
rats.
These results suggest a new potential for
valsartan in the therapy of ischemic heart disease
and chronic congestive heart failure but need
further clinical investigations |
