Lacidipine is" a new 1.4 dihydropyridine derivative designed
to have -a pOtent vascular selective antagonistic activity. The
present study was carried out to screen the pharmacological effects
of lacidipine on isolated rabbit aortic strip. Also, the effect
of lacidipine on atherosclerosis induced experimentally in,
rabbits was studied. Moreover, the effect of lacidipine on LNAME
induced hypertension in rats was evaluated. Data obtained
in the present study -pointed out that lacidipine produced
significant decrease (P < 0.05) in the KCI-induced contraction
of isolated rabbit aortic strip. Also, lacidipine antagonized norepinephrine
and angiotensin H induced contractions of isolated
rabbit aortic strip. Moreover,: lacidipine produced a protective
effect on experimentally induced - atherosclerosis in rabbits.
Further more, lacidipine exerted antihypertensive and nephroprotective
effects'in the model of L-NAME induced hypertension
in rats.
These results suggests a potentially emerging important role
of lacidipine in antagonizing hypertension and renal structural
and functional consequences associated with chronic NO synthesis
inhibition. So. lacidipine ma) have a promising role in management
of many deleterious conditions associated with decreased
NO production e.g. cardiomyopathy and stroke. |
