Cerebral ischemia is a major leading cause of death and at the first place cause of disability all over the
world There are a lot of drugs that are in experimental stage for treatment of stroke. A mong them are
statins and calcium channel blockers that have, in animal models, dfferent effectiveness in healing of
ischemic damage in brain. Their mechanisms in cerebral ischemia is still unclear, but antioxidative, antiinflammatory
and neuroprotective properties is supposed to be implicated In the present study, we
investigated antioxidant, anti-inflammatory and neuroprotective properties of HMG-CoA reductase
inhibitor (Rosuvastatin) and calcium channel blocker (Amlodipine). Methods administration of
Rosuvastatin (20mg/kg/Ip) and Amlodipine (3.2mg/kg/lp) just after induction of cerebral ischemia in male
albino rats. Cerebral ischemia was induced by temporary occlusion of left common carotid artery for 60
min. ,then stroke index(SI) was calculated at day 4 after ischemia, behavioral test (cyclic & placing test)
were performed Rat were sacrified and area of cerebral infarction was measured serum superoxide
dimutase (SOD) enzyme, glutathione peroxidase (GHPx), Malondihydryde (MDA), C-reactive
protein(CRP)and total cholesterol level were also measured The present result reveald that vehicle
ischemic group produced high stroke index, extensive cerebral infarction and behavioral deficit. Also, it
significantly decreased serum SOD, GHPx, and increased MDA, CRP. treatment with Rosuvastatin and
Amlodipine significantly ameliorated SI, cerebral infarction, behavioral deficit, SOD, GHPx, MAD, CD
without affection of serum cholesterol level. This improvement was more pronounced in the group
receiving both drugs together. These findings suggest that Rosuvastatin and Amlodipine have
neuroprotective effect against cerebral ischemia induced behavioral deficit and neuronal degeneration
that may be mediated through antioxidant, anti-inflammatory mechanisms in normocholesterolemic rats. |
