In this study, the effect of angiotensin-11 receptor antagonist (Candesartan)
was evaluated on the portal venous pressure and angiotensin II plasma level in
normal and experimentally induced portal venous hypertension in rabbits (PHI)
(by partial ligation of portal vein for 3 weeks). It was found that candesartan
administration reduces the portal venous pressure insignificantly from 7.23 ± 0.47
mmHg in control group to 6.96 ± 0.32 (P >0.05) and caused an insignificant
increase of angiotensin-11 plasma level from 6.98 ± 0.63 pg/ml in control group to
7.75 ± 0.39 pg/m1 (P> 0.05). However, after partial ligation of portal veins, the
portal venous pressure rises to 13.53 ± 0.51 mmHg, and decreased significantly by
Candesartan to 8.7 ± 0.86 mmHg (p < 0.001). Moreover, angiotensin-II level
increased in PHI rabbits to 11.77 ± 0.65 pa/m1 (P <0.001) and insignificantly
increased by candesartan to 12.66 ± 0.67 pg/ml. (P > 0.05). In conclusion,
angiotesin-II receptor antagonists may be of great value in treatment of patients
with portal hypertension and esophageal varicet |
