In spite of the evidence suggesting that many cannabinoid addicts are
victims of infertility, Vet there is little inforniation about the extent of fertility
affection and whether it is uniform on all fertility parameters or not. In order to
clarify these issues, the effects of acute and chronic cannabinoid agonist
(bango) inhalation on. different semen parameters, serum gonadotrophins,
prolactin levels and testicular functions were studied. The results of this study
revealed that acute bango inhalation resulted in a statistically significant
reduction in sperm viability (p-:0.05) and motility (p<0.05), decrease in serum
LH (p<0.05) and prolactin (p<0.05) levels, while FSH showed insignificant
changes (p>0.05). Chronic bango inhalation resulted in a statistically significant
decrease in sperm cell count (p<0.001), viability (p<0.001), motility (p<0.001),
increase in abnormal forms (p<0.001), decrease in serum LH (p<0.05) and
prolactin (p<0.01) levels, while FSH showed insignificant changes (p>0.05).
Chronic bango inhalation caused a marked degenerative changes and depletion
of spermatogenic cells in most seminiferous tubules augmented by concomitant
inhalation of tobacco and bango which did not return back to normal levels after
30 days of treatment termination. In conclusion, bango inhalation has a serious
deleterious effects on male fertility and sex hormones. |
