Background: High salt diet is independent determinant of left
ventricular hypertrophy in addition to cardiac and renal fibrosis.
Angiotensin II has possible role in mediating these deleterious
effects. This work was designed to evaluate the possible effect
of ATI receptors blocker, candesartan on pathological change in
heart and kidney induced by high salt diet (8%).
Materials and methods: High salt diet (8%) was administered
to 30 male albino rats for eight weeks to induce left ventricular
and renal hypertrophy and fibrosis. Candesartan in therapeutic
equipotent dose in human (0.02mg/kg/day orally) was started
one week before (prophylactic group) or five weeks after (curative
group) starting high salt intake. By the end of eighth week
from starting high salt diet intake, blood pressure was recordedm
rats were sacrified heart and kidney were removed, weighed and
pet-pared for pathological examination.
Results and conclusion: Candesartan caused significant improvement
in all parameters studied although the improvement
was more evident in prophylactic than curative group. High salt
intake (8%) induced hypertension ,cardiac and renal hypertrophy
with fibrosis in albino rats. These histological changes can be
avoided or cured to a great extent by oral administration of ATI
blocker, candesartan. Angiotensin II may play a role in these
deleterious changes induced by high salt diet.
|
