AIM: To study the effects of ferulic acid on gastrointestinal
motility both in vib-o and in vivo.
METHODS: Ferulic acid induced concentrationdependent
stimulation of the basal tone of isolated
guinea pig ileum (2-20 pmol(L) and isolated rat fundus
(0.05-0.4 mmofft).
RESULTS: Ferulic acid significantly accelerated the
gastrointestinal transit and gastric emptying in rats in a
dose-dependent manner (50-200 mg/kg, po). Cisplatin
(2.5-20 mg/kg, ip) induced a dose-dependent delay in
gastric emptying in rats. Pretreatment with ferulic acid
dose-dependently, significantly reversed the cisplatininduced
delay in gastric emptying.
CONCLUSION: The endogenous prostaglandins (PGs)
are involved in mediating the stimulant effects of ferulic
add. This effect of dietary ferulic add may help improve
other accompanying gastrointestinal symptoms such
as abdominal discomfort and also may protect against
emesis induced by cytotoxic drugs. |
