The present study inv‘stigatts the effects induced by sildenafil (0.004 and 0.008 mg/gm p.o.) on
copulatory behavior of male rats. performed on sexually inactive male rat model against sexually highly
receptive females. Also, it reviews current evidence regarding its central sexual effect on decreased desire
(libido) arousal difficulties aid orgasm. Parameters of sexual behavior were assessed including mount,
intromission. and ejaculation latencies and frequencies. Also. serum follicle-stimulating hormowe iFSH).
luteinizing hormone ti.H) awl prolactin levels were checked in sexually inactive rats in comparison to
control and normal intact rats. The data obtained show that sildenaftimodifies both sexual arousal and
ejaculatory mechanisms of opulation. It appears that, although it induced a facilitatory effect on
ejaculation of all rats. the Icceting of ejaculatory threshold was achieved by means of a redaction of
mount frequency and intromission frequency in both sexually inactive rats and those with normal sexual
activity. Sildenafil increased sexual arousal, in both sexually inactive and rats with normal sexual
activity. It was (mind that, in sexually inactive rat model there was a statistically significant decrease in
mount, intromissioo and ejaculation latencies (p<0.05 ; p<0.05 and p<0.05 respectively) and a
statistically significant detrerie in mount and intromission frequencies (p<0.05 and p<0.05). Serum FSH,
LH and prolactin levels showed a statistically non-significant changes. All other parameters showed a
statistically significant imprevement after administration of sildenafd (0.004 and 0008 mg/gm. p.a.).
Finally, sildenaftl has a great impact on sexual functions both centrally and peripherally. |
