The effect of adrenergic blockade on oogenesis and maturation of graafian
follicles in female albino nts NILS investigated. Subcutaneous injection of propranolof
(non selectit e, cross blood brain barrier) In a dose of 3 mg /kg/ dav for
caused 4 weeks
insignificant changes in the average num ber of growing and mature graafian
follicles in animals sacrificed at proestrous. Also, the same dose of propranolol for
the same duration caused insignificant changes in the average number of growing
crag-
Lan follicles and corpora lutea in the animals sacrificed at metestrous.
Subcutaneous injection of propranolol in a dose of 5 rug /kg/ day for 8 ueeks. caused
significant reduction (P <0.0$) in the average number of growing graafian
follicles and corpora lutea in animals sacrificed at metestrous.
Nadolol (non selective, doesn't pass blood brain barrier') In equipotent dose
to s mg acgt propranoloi (53 mg fkg) KU Injected subcutaneously daily for 8 weeks
also caused reduction (P <0.(15) on the 10 enge number of growing graaftan follicles
Enticed at melestrous. Metoprolot lSelectise beta,
and corvette lUtta in the animals sacrificed in equipotent dose to 5 mglkg propranolol
blocker,
doesn't pass blood brain barrier)
nvglicg) w as
injected subcotancoush dall for % meeks caused Insignificant
thane 0, > 0.05) on the
average number of growing
graaftan tollicks and corpora
lutea in the animals sacrificed at metestrous.
Propranolol (Smg/kg) and Nadolol (5.5
mg /kg) injected subcutaneously daily
for 8 weeks caused no effect on ovulation Induced by pregnant mare serum
gonadotrophin.
The effect of propranolol in a dose of Smg
/kg/ day for 8 %4 in the animals kept without administration for 4 weeks more. eels was reversed
The above results suggested
that propranolol and nadolol caused significant
reduction in the process of oogenesis and ovulation. Metoprolol caused insignificant
effect.
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