This work aimed to evaluate the effect of sertraline, as an antidepressant
agent, on the histogenesis and development of kidney of embryo in female
pregnant rats. Pregnant female albino rats were adminstered 5mg/kg /day
sertraline intraperitonially starting on 2nd of gestation till the day llth for ten
doses.The control group received saline by the same way and the same duration of
treated group.At the days 12 and 18 the kidney of embryos of both groups were
assessed morphologically and histologically. The kidney of treated embryos
showed growth retardation,less differentiation and necrosis in both ages with
variable degrees. Retardation of growth indicated by decrease in number of renal
corpuscles and renal tubules. Proximal and distal connvoluted tubules were not
completely differentiated with cystic dilatation of some of them mainly at 18
days. Their was loss of normal pattern of renal corpuscles with dilatation of their
capillary tufts. Necrosis was observed in the cells of renal tubules and
mesenchymal cells.
These results suggest that the use of sertraline as antidepressant agent
during childbearing period may affect the morphological and histological
development of renal structure of the embryo. So, the results recommend to
potentially avoid the use of this medication during gestation. |
