The present work aimed to clarify and investigate the beneficial or toxic effects of aqueous
garlic extract (AGE) on haematological and biochemical parameters as well as histological
structure of both the liver and kidney. Sixteen normal male albino rats weighing (300-370g)
were divided into two equal groups. The first gourp did not take any medication and used as
a control. The second one received AGE in a dose of 600mg/kg/day intragastrically as a
single dose for 28 days. Haematolgically, the garlic extract improved blood parameters and
haemoglobin level. Biochemically, the extract induced hypoglycaemic, hypolipidaemic
effects and improved liver and kidney function related parameters. Microscopic examination
of the liver of garlic-treated rats revealed hepatocytes with less cytoplasmic vacuolation and
more vesicular nuclei, dilated blood sinusoids and arterioles with increase in Von Kupffer
cells. There was an increase In acidic mucopolysaccharides mainly around of bile duct and
the wall of arterioles. While the kidney showed renal tubules with acidophilic cytoplasm and
vesicular nuclei. There was hyperplasia of mesangeal cells of the glomeruli with a slight
decrease in collagenous fibres and an increase of acidic and neutral mucopolysaccharides
mainly in renal tubules, blood vessels and basement membrane.These results suggesed that
aqueous garlic extract improves various haematological and biochemical parameters as well
as it gives a cytoprotective effect to the tissues of liver and kidney. |
