This study was carried out to determine the effect of chlorpromazine
(6.7ing/kg) on scrum cortisol and blood scrotonin (51IT) in chronic
schizophrenic patients. Results of the present work revealed that, scrum
cortisol level was non significantly altered prior to the initiation of
treatment or after one month of drug treatment .Moreover , blood 51-IT
was significantly elevated in chronic schizophrenic patients and was
significantly reduced approaching control level by chlorpromazine. This
indicating that hypothalamic-pituitary- adrenal regulation is less disturbed
in schizophrenia, and elevated 51 IT level may has a role in the
pathogenesis of schizophrenia, mid its reduction may be one of the
therapeutic ends of anti psychotic drugs
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