In the present study, moxonidine, an I I-a2 receptor agonist,
produced concentration ii related contraction of the rabbitis
aortic spiral strips. This contractile effect of moxonidine was
significantly antagonized by yohimbine, but not to the same
extent by praz,osin. Chronic moxonidine treatment of DOCASalt
hypertensive hyper-cholesterolemic rats induced significant
reduction of blood pressure and heart rate, in addition, it
produced a significant decrease in total cholesterol, triglyceridies
and LDL-cholesterol levels. Moxonidine treatment resulted
in a significant decrease in serum sodium with no
change in serum potassium and serum creatinine in hypertensive
hypercholesterolemic rats. Moxonidine favourably affected
renal and hepatic hemodynamic parameters in both hypertensive
and normotensive rats. Moreover it improved the
histopathological picture of the liver and exhibited a renoprotective
effect appeared in the form of increasing renal blood
flow velocity with improvement of glomerulosclerosis. |
