The present work aimed to clarify and investigate the beneficial or
toxic effects of some commonly used natural compounds; Royal Jelly,
Nigella sativum ( Baraka oil) , Allium sativum ( garlic oil) and Omega - 3
fatty acids . Their effects on long - term administration in male albino rats
fed high cholestrol diet for two months were studied . The effects
investgalted were their action or blood lipid profile ( total cholesterol,
triglycerids , high density lipoproteins ( H D L) and low density
lipoproteins ( L D L) as well as their histopathological effects on blood
vessels versus the commonly used antiatherosclerotic drug ; bezafibrate .
Also their effects on some biochemical parameters ; liver function tests
( as Albumin, bilirubin , A L P, SGOT and SGPT ) and kidney function
tests ( as serum creatinine and urea) .
Also effects of these compounds on the immune system were
investigated by measuring the T- lymphocyte and IgG titres.
Animals were divided into 7 groups ( each was 10 rats) ; normal group
( fed only standard diet for 2 months ) , atherosclerotic group ( fed high
cholesterol, 100 mg / kg / day p . o ) for two months , other five groups
fed high cholesterol diet for 2 months and taken orally Royal jelly ( R.
J)
, Nigellar ,, Omega- 3 fatty acids, garline and bezafibrate respectively.
From the results of this study it can be concluded that all compounds
used had a significant protective effect on the lipid profile and blood
vessels and can be used in prevention of progression and development of
atherosclerosis . We found also that these compounds have a beneficial
effect on the immunity systen as they have an immunostimulant effect
except Omega 3 - fatty acids ( which have an inununosuppressant effect)
on long term administration.
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