This work was done to evaluate the possible beneficial
effects of the calcium channel blocker ( isradipine ) and the
Angiotensin - Converting enzyme inhibitor (ACEls ) ( lisinopril )
on acute renal failure ( ARF ) induced by dehydration and glycerol
in male albino rats either prophylactically or curatively.
Animals were classified into 7 groups, each has 10 animals:
normal control group, uremic prophylactic control group, uremic
curative control group, uremic treated with lisinopril
prophylactically group, uremic treated with lisinopril curatively
group, uremic treated with isradipine prophylactically group and
uremic treated with isradipine curatively group.
The results of this work indicate the ability of isradipine to
improve the biochemical parameters ( urea, creatinine, sodium,
potassium and calcium) and histopathological parameters of acute
uremic rats both prophylactically and curatively while lisinopril
failed to do that effect.
The above results suggest the possibility of using isradipine
in treatment of acute renal failure or as a prophylactic when acute
renal failure is predicted. |
