Publications of Faculty of Medicine:Evaluation Of Preoperative Localization Of Parathyroid Adenoma Using 99mTc-sestamibi Scintigraphy As A Single Diagnostic Modality For Patients With Primary Hyperparathyroidism: Abstract

Objective : This- study was designed to evaluate the diagnostic yield Of Technetium-99m hexakis methoxyisobutylisonitrile (Tc-99m-MlBl) scintigraphy in patients with primary hyperparathyroidism (FHPT) for identification of the site of parathyroid adenoma compared versus operative and histopathological findings. Patients & Methods : The study included 13 cases with PHPT; 5 males and 8 females with mean age of 56.5+10.3: range: 39-69 years. Preoperative scanning using 9$mTc-sestamibi was done. All patients underwent surgical exploration after methylene blue transfusion. Imaging data were compared with intraoperative finding. AJ identified and excised glands were sent for histopathological examination. Results : Preoperative sestamibi scan defined a case with mediastinal parathyroid gland and another active cervical gland in 2 patients with persistent and recurrent hyperadcaemia, respectively. Preoperative sestamibi scan defined 6 cases with single parathyroid adenoma in each case, while surgical exploration defined 7 parathyrpidttdenomata; 5 cases had solitary adenoma and one case had adenoma in 2 parathyroid glands both stained blue after methylene blue infusion. Thus, sestamibi scan defined solitary parathyroid adenomas with an accuracy rate of 83.3%. However, sestamibi scan defined 3 cases with adenoma in 2 parathyroid glands and 2 cases had adenoma in 3 glands. Surgical exploration defined adenoma that