Abstract
The cyclosporine is now established as the immunosuppressant of
choice in human organ transplantation, because it improves graft survival.
Unfortunately, the cyclosporine can lead to a wide spectrum of nephrotorir
complications. The aim of this study was to asses the effect of lacidipine
(a calcium antagonist) on the cyclosporine induced nephrotoxicity
in rats. Thirty adult albino rats were used in this shady. They were divided.
into three-groups: a control group, a cyclosporine group and a lacidipine
freated group. The rats of cyclosporine group had received an oral
dose of 50 mg cycicisporine/ kg body weight daily for two weeks. The rats
• of lacidipine treated group had also received the same dose of cyclospo-
• rine for 14 days along with lacidipine lmg / kg body weight daily by oral
administration three days before and fourteen days concurrently with the
cyclosporine drug. At the end of the experiment, there was marked elevation
of serum urea and creatinine levels in the cyclosporine group. Lacidipine
treatment significantly (P .< 0.05) reduced the elevated serum urea
and creatirtine. In control group, the histological examination of the rat renal
cortex showed normal glomeruli and normal Bowman's capsule. The
tubules which were seen in the sections consist mainly of the proximal
convoluted tubules and some distal convoluted tubules. The proximal convoluted
tubules are lined by columnar cells with rounded nuclei and
prominent nucleoli. These cells have many microvilli which form a brush
border. The cytoplasm of these cells contains mitochondria, few vesicles
and small sized lysosomes. The renal corpuscles and tubules are surrounded
by minimal amount of loose connective tissue. In cyclosporine |
