Publications of Faculty of Medicine:Low-pressure pneumoperitoneum could decrease postoperative alterations of hemodynamic variables and pulmonary function tests after laparoscopic cholecystectomy: Abstract

Objectives: To evaluate the impact ofpnettmoperitoneum on pulmonary fiinctions, hemodynamic variables and frequency and intensity of shoulder tip pain (STP) in patients undergoing laparoscopic cholecystectomy (LC). Patients & methods: Fifty chronic cakular cholecystitis patients were allocated to highpressure (HP) group (13-15 mmHg) and low-pressure (LP) group (9-11 mmHg). Mean arterial pressure (MAP), and heart rate (HR,) measurements were obtained before (TI), after induction of anesthesia (T2), 5 min. before (T3), after insufflation (T4), 5 min. after tilting in reverse Trendelburg position (T5) and after exsufflation of CO2 (T6). Duration of surgery, occurrence of intraoperative complications and conversion to laparotomy, time till . first ambulation, .first oral intake and length of postoperative (PO) hospital stay were recorded. Severity of PO STP was assessed using visual analogue scale at 3, 6, 12, 24, and 48 hours. Forced vital capacity (FVC), forced expiratory volume in 1 sec (FE Vi) and FEV1/FVC ratio were estimated 24 hours prior to and after surgery. Results: All patients passed smooth intraoperative course without complications or conversion to laparotomy. Mean operative data showed non-significant difference between both groups. At T4 and T5 HR and MAP measurements were significantly higher in HP group despite the significant difference compared to other measures in both groups. Twenty-three patients had STP with significantly higher frequency and intensity in HP group. Mean duration till request of analgesia was significantly longer in LP group. Pneumoperitoneum altered PO pulmonary function tests compared to preoperative values with significantly altered FE VI evaluated as the percentage of change in HP group. Conclusion: Pneumoperitoneum irrespective of the pressure used affects pulmonary function tests and induces hemodynamic changes with precipitation ofSTP; however LP allowed significant amelioration of these effects despite that it could not abolish it, so it allows getting the advantages of laparoscopic surgery with minimal hazards. Key words: Pneumoperitoneum, low pressure, pulmonary function tests, shoulder tip pain.