Abstract:
Carbendazim is a systemic benzimidazole lengicide that plays a very important
role in plant diseases control. Carbendazim can disrupt the development or the sperms;
induce Satoli cell delimitation and toxic to male reproductive mechanisms. The
Present study was developed to investigate the toxic effects of carbendazim on the rat
testis. In the present study, 50 male adult albino rats were used. Their body weight
ranged from 200-350 grams. The rats were divided into three groups ; control group (10
rats), low dose treated group (20 rats) that were given a daily oral dose of carbendazun
( 25mg / kg / body weight ) liw one week and high dose treated group (20 rats), that
were given a daily oral dose of carbendazim (400mg / kg /body weight) ler one week.
The results of this study revealed that carbendazim caused sloughing of the germ cells
and vacuolization of the epithelium ()I' the seminiferous tubules. In cells
infiltration was also noticed. The results of the present study showed that carbendazim
affected the shape of Sertoli cell and its nucleus. The results also revealed that
carbendazim arrested the mitotic activity of the germ cells. Ultrastructural study
showed that carbendazim caused attenuation of the acrosomal cap, degeneration of
spermatogenic cells and arrest of cellular divisions. The present study proved that the
effects of carbendazim were dose dependent where Hie deleterious effects were
Increased with high dose of carbendazini than with low dose. |
