The effect of infection by Chlainyclia pneumoniae (C. pneumoniae) and Helicobacter pylon (H.
pylori) on patients with coronary heart diseases (CHD) was investigated. 40 patients; 20 suffered from
acute myocardial infarction (AMI) (Group I) and 20 suffered from angina (Group II) were selected as
patient groups. 20 clinically healthy persons of the same age were selected as a control group (Group
III) . The patient groups were subgrouped according to the most important risk factors for CHD
(smoking, hypertension, and hypercholesterolaemia). The level of C. pneumoniae IgG & IgM and H.
pylori IgG were detected in the sera of the three groups. It was found that C. pneumoniae IgG was
positive in 18%, 14%, and 4% with mean titre 364.8, 380.7, 12.8 (in groups I, H, and III respectively)
which was significanly higher in group I and II than group HI. C. pneumoniae IgM was negative in
groups I and III, while it was positive in 15% of group II with mean titre 275.6 with a statistical
significance among the three groups. H. pylori IgG was positive in 60%, 50%, and 45% with mean
concentration 312.2, 315.4, and 151.3 on groups I, H, and HI (respectively) with insignificant
difference among the three groups. As regards to smoking status, C. pneumoniae IgG was higher in
smokers than in non smonkers in groups I and II with significant difference in group I only. C.
pneumoniae IgM was insignificant in both groups. H. pylori IgG was high in smokers in both groups
with non significant difference. Concerning blood pressure. C. pneumoniae IgG, IgM and H. pylori
IgG in both groups were high in hypertensives with no significant relation among them. As regards to
cholesterol level, the mean titres of C. pneumoniae IgG and IgM were high in hypercholesterolaemic
patients in both groups with no significant relation among them, while the mean concentration of H.
pylori IgG was high in hypercholesterolaemics in both groups with a significant difference in group I
only. We concluded that, infection with C. pneumoniae and to a lesser extent H. pylori may play a role
in the pathogenesis of CUD and their treatment may enhance the recovery of the disease. |
