Background: Previous studies have suggested that "intercellular adhesion molecule-1
(ICAM-1 CD54) may be involved in the pathogenesis of asthma.
Methods: This study is a cross-sectional cohort study on 40 asthmatics as well as 20
age and sex matched controls. They were subjected to all routine investigations and to
some immunological parameters. Concentrations of S-ICAM-1 were measured in sera
of asthmatics and control; to determine whether bronchial asthma is associated with
increased levels of s-ICAM-1 in serum and to assess the effects of therapy on these
levels.
Results: The mean (± SD) level of serum s-ICAM-1 for 40 asthmatic children during
attack (488.05 ± 123ng/m1) was significantly higher than that of 20 controls (270 ±
85.18 ng/ml; p <0.001). Also there was a significant difference in (S-ICAM-1) mean
level (± SD) during attacks and after remissions among asthmatic 40 children (488.05
± 123 ng/ml) and (397.8 ± 104 ng/ ml) respectively while p <0.001. Moreover we had
24 asthmatics considered to be atopics and 16 asthmatics ware non-atopics did not
differ significantly in their level of (s-ICAM-1), (P = >0.05) either during attack or
remission.
Conclusion: Active bronchial asthma is associated with the presence of increased
level of S-ICAM-1 in serum, these levels may be modulated by therapy. We
postulated the usage of anticytokines in treatment of bronchial asthma in future. |
