For assessing the role of circulating
immune complexes (CIC) in
chronic hepatitis, the relative frequency
of CIC was determined in 20
patients with chronic hepatitis B
(CHB), 30 patients with chronic hepatitis
C, 20 asymptomatic hepatitis C
virus (HCV) carriers, and 15 healthy
controls. IgG containing CIC were
studied using Clq enzyme immunoassay.
Elevated IgG-CIC was detected in
16 out of 20 (80%) patients with CHB
compared to none (0.0%) in the
healthy control group, a difference
which is statistically significant (P <
0.01). Also elevated IgG—CIC was detected
in 22 out of 30 (73.33%) patients
with ClIC compared to 2 out of
20 (10%) chronic hepatitis C carriers
and none (0.0%) in the healthy control
group, a difference which is statistically
significant (P < 0.01). The concentration
of IgG-CIC was significanth
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group. The average values were 42.75
pg eq/ml for CHB patients, 40.37 for
CHC patients, 16.0 for HCV carriers
and 15.33 for healthy controls. |
