Publications of Faculty of Medicine:RELATION OF CHLAMYD1A PNEUMON1AE IgM & IgG, HELICOBACTER PYLORI IgG, SERUM INTERLEUKIN 6 AND CRP IN PATIENTS WITH CRESENDO UNSTABLE ANGINA AND ACUTE MYOCARDIAL INFARCTION: Abstract

The effect of infection by Chlamydia pneumoniae (C. pneumoniae) and Helicobacter pylori (H. pylori) on patients with coronary heart diseases (CHD) was investigated. 50 patients, 25 had acute myocardial infarction (AMI) (Group I) and 25 had emend° unstable angina (croup II) were selected as patient groups. 20 clinically healthy persons of the same age were selected as a control group (Group HI). The patient groups were subgrouped according to the most important risk factors for CHD (smoking, hypertension, hypercholesterolaemia, and high triglycerides ). The level of C.pneumoniae IgG & IgM ,11.pylori IgG ,114 and CRP were estimated in the sera of the three groups. It was found that C.pneumoniae IgG was positive in 88%, 72%, and 35 (1/0 in groups I, II, and III (respectively )which was significantly higher in group I and II than in group III. C.pneilinoniae IgM was positive in 4%, 20% and 0% in groups I, II, and 111( respectively) which was significantly higher in group I and II than group III with a statistical significance among the three groups. li.pylori IgG was positive in 60%, 48%, and 45% in groups I, II, and III (respectively) with insignificant difference among the three groups. As regards to smoking status, C.pneumoniae IgG was higher in smokers than in non smokers in groups 1 and II with significant difference in group I only, while C.pneumoniae IgM was insignificant in both groups. H.pylori IgG was high in smokers in group I (86.7%) than in group!' (52.9%) with non significant difference. Concerning blood pressure, C.pneumoniae IgG, IgM and H.pylori IgG in both groups were high in hypertensives with insignificant relation among them. As regards to cholesterol and triglycerides levels, C.pneumoniae IgG ,IgM and H.pylori IgG were high in patients with high levels of cholesterol and triglycerides in both patients groups with insignificant relation among them. IL6 and CRP were significantly elevated in groups I and II particularly in patients with serological evidence of C.pneumottine.We concluded • that, blocking the activity of IL6 might result in a decrease in acute coronary syndrome severity and can be viewed in light of a .reduction in cardiovascular events in unstable angina and in survivors of myocardial infarction after antibiotic treatment for Cpiteumonice.,