This study aimed to evaluate the role of Anti-Cyclic Citrullinated Peptide (anti-CCP) antibody in comparison
to Cartilage oligomeric matrix protein (COMP) in Rheumatoid Arthritis (RA) patients as predictors of the
disease activity and cartilage destruction. The study included 60 patients &10 apparently healthy subjects.
They were divided into 4 groups. Group!: consisted of 20 patients with established rheumatoid arthritis( and
positive rheumatoid factor)Group 2: 20 suspected (rheumatoid factor negative) patients Group 3: 20 patients
with other autoimmune inflammatory diseases (15 with psoaritic arthritis, 5 with systemic lupus
erthromatosis).and Group 4: 10 age and sex matched controls. For each patient medical examination and
disease activity evaluation using Disease Activity Score (DAS) was performed Anti cyclic citrullinated
peptide (anti CCP) level was measured by ELISA method and cartilage oligomeric matrix protein (COMP) was
determined by indirect immune fluorescent method. Serum level of anti CCP antibodies and COMP were
Significantly related to DAS (disease activity score) and cartilage destruction, the serum presence of COMP
was highly significant in rheumatoid arthritis patients than those with other autoimmune disease, the
sensitivity of anti CCP in diagnosis of RA was 77.5% and specificity was96.6°A. It is concluded that anti CCP,
and COMP may be a useful noninvasive markers for disease activity and cartilage destruction. |
