Syno vial fink] front the knee joints of 20 psoriatic arthritis patients (8 with polyarthritis and 12 with mono / oligoarthra is) were studied to detect the vol'p of interleulcin-1 beta. ESE? and serum C-reactive protein were also measured. Quantitative immunoassay method showed a significant increase of interleukin-1 beta in the synovial fluid of polyarthritis group as compared to mono/ oligoarthritis group, while. ESR. C-reactive protein and synovial fluid total protein, acid phosphatase and WBCs showed non significant changes between the two groups. So. the synovial fluid interleukin-1 beta is one of the parameters which differentiate between the two groups. Synovial fluid interleukin-1 beta showed significant correlation with the number of affected joints and joint score and non-significant correlation with ESR and C-reactive protein. Results confirm the role of interleukin-1 beta in the pathogenesis of psoriatic arthritis as well as to select those who will be in need for aggressive and non con- ventional treatment |
