| Title: | The role of Anti-Saccharomyces cerevisiae Immunoglobulins (IgG,IgA) And Atypical Perinuclear Antineutrophilic Cytoplasmic Antibody In Diagnosis And Classification Of Inflammatory Bowel Disease |
| Full paper | Not Available |
| Abstract: |
inflammatory bowel disease (IBD) is the general term used for a heterogeneous group of intestinal disorders, including Crohn's disease (CD) and uleetutive colitis (11C). Questions are raised about the value of serological markers suds as anti-S'accharomyres cerevisiae antibodies (ASCA) IgG and atypical perbutelear antineutrophil it- cytoplasmic antibody (at.vitical pAN(A) in the diagnosis and differentiation elf CD and VC. ASCA inununogiobulin A (IRA) antibody is said to have clinical utility in diagnosing 113D, specifically in ASCA IgG-negative CD patients. Aim of Work: The aim of this .vtudy was to deter ane if these markers can replace ordinary invasive methods for diagnosis and classification of 11130 and whether they helve predictive role in prognosi.v of 1130. Subjects and Methods: 57 sub/ens (45 patients and 12 can/p ls) were included in this study. Patients nvn• subjected Ia full history taking, thorough medical aMila10011, radittiogitat endoscopic and hishmathological examination. 5m1 of blood were retrieved .from all subjects and assayed by Enzyme Linked Inummosorbent Assay (ELISA) for quantitative measurement of ASCA (IgG and IgA) and pANCA. Results: There was significant increase in ASCA IgG and IgA in CD patients and pANCA in UC patients when compared with comm! subjects. Sensitivity , specificity , positive predictive value (PPV) and negative iwedictive value (NPV) of ASCA IgG IcA in CD and pANCA in (IC when compared with controls were (50, 86.3, 8.5.7, 25%), (25.5, 66.67, 75. 18.18%) ,and (50. 66.67 75. 40%) respectively . While AS( A+ ve //Mil/CA-re comhinathm Jim Ca and ASCA -re / pAN(A+ re for II( hull set/sit/0/it pe•t situ it l'I'V null NIT 4(3.1.6. ION, mu, 26.09(x )(mil 03.33. lop • 12.8(,%) respective, y. AS( A Igt; was elevated in penenating and structuring type of Cl) and more in proximal colitis than di.vial parts .Conclusion: ASCA (IgG and IgA) and pANCA are useful toolv for diagnosis and classification of IBDs if used in combination, but not alone . Key Words: ASCA (Anti-Saccharomyces cerevisiele antibody) — pANCA perinudear antineutrophilic cytoplasmic antibody— 1130 (Irritable bowel disease) — Crohn's disease — Ulcerative colitis |