Publications of Faculty of Medicine:THE VALUE OF ,VERUM LEVELS OF INTERIEUR- IN-111 INTERIEUR -IN-6 AND CIRCULATING VASCULAR CELL ADHESION MOLECULES AS 414RKERS OF DISEASE ACTIVITY IN TYPHOID FEVER PATIENTS : Abstract

The present stud) was carried to evaluate the value of interleukin-Ift (IL-1 interleukin -6 (IL-6) and circulating vascular cell adhesion molecules (sVCAM) as a markers of disease activity in typhoid fever Thirty nine patients were selected from patients attending the Department of Hepatolog), Gastroenterolo*. and Infectious Diseases of Benha University Hospital and diagnosed as enteric fever and by bacteriological examination of stool and blood and by Widal test. Ten healthy individuals were examined ,control group .From all patients 24/39 patients were diagnosed as typhoid fever. The level of IL-1I3,IL-6 and sVCAM were measured in the serum of typhoid fever patients pre and after treatment with anti-typhoid drug ( pefloxacin) by antigen capture ELISA .Before treatment ,serum levels of IL-1 11 and I1-6 were significantly elevated in typhoid fever patients when compared with healthy controls (P< 0.01),and no significant change was reported in the level of sVCAM .After treatment ,scrum IL-6 and sVCAM were significantly declined in patients sera as compared with their levels before treatment (P< 0.01) .No significant change was reported in the scrum levels of IL-1 in typhoid patients after treatment as compared with its level before treatment, also no significant change was reported in its level in the serum of responding and nonresponding patients to treatment . IL-6 and sVCAM were significantly declined in the serum of patients responded to treatment when compared with patients not responded to treatment (P <0.05). IL-6 had the best discriminative power in identifying active typhoid fever, being elevated in serum before treatment and was declined in the patients serum after treatment .Our data support the possibility that 1L-1 and IL-6 may be involved in the pathogenesis of typhoid fever and IL-6 may be a useful marker of disease activity and curing.