Introduction : The presence of particuiarly high serum levels of IL-IRA in patients
with PM / DM is indicative of distinct pathologic mechanism , also measurement of
IL-IRA , together with clinical examination may provide useful information tor the
follow up of PM / DM. patients .
Aim of the work: is the determination of the serum level of It- IRA and its
relationship to different clinical and laboratory parameters of inflammatory
myopathies.
Patients and Methods: This study was carried on 20 patients suffering from
inflammatory and non inflammatory muscle diseases and ten healthy controls . Full
history taking and thorough clinical examination together with routine laboratory
investigations , interieukin -1 receptor antagonist, creatin kinase, C- reactive protein
were measured in the serum of all subjects .
The results of the present study showed that the serum levels of CK and CRP were
significantly higher in the patients than controls , while IL-IRA and CRP were
significantly higher in DM/PM group than non-inflammatory and control groups, no
significant difference was found between the serum levels of IL-IRA in
non-inflammatory muscle disease and controls , also non significant difference between
CK level in inflammatory and non inflammatory muscle diseases was found . A
proportional correlation was found between IL-IRA and F.D.G & CK in the patients
while inverse correlation was found between IL-IRA and M.G
Conclusion: These results indicated that Inflammatory myopathies showed certain
immune activation as shown by increased IL-IRA in the patients which can be used as a
marker of early detection of the disease . |
