Our aim was to evaluate paraoxonase activity and to determine the prevalence of
some antiphospholipid (aPL) antibodies to assess their association and their predictive
value for vascular complications in premenopausal women with systemic lupus
erythematosus (SLE). This study was carried out on 25 premenopausal patients with
SLE. Twenty age matched apparently healthy premenopausal females were also
recruited as a control group. Paraoxonase activity was measured by quantification of
p-nitrophenol formation. Serum levels of IgG and IgM anticardiolipin (aCL) antibodies
and IgG anti-high-density Iipoprotein (anti-HDL) antibodies were measured by
enzyme-linked immunosorbent assay (ELISA). Total cholesterol and HDL cholesterol
were determined by standard enzymatic techniques.
Paraoxonase activity was low in SLE patients compared with controls , Total HDL
level was reduced, Anti-HDL antibody levels were significantly higher ,IgG and IgM
aCL antibodies had higher concentration in patients with SLE
Paraoxonase activity showed a significant negative correlation with age, disease
duration , IgG anti-HDL and SLEDAI, but not with IgG or IgM aCL antibodies. In
conclusion, the results of the present study revealed that IgG anti-HDL antibodies.are
associated with reduced paraoxonase activity in patients with SLE. Since the physiologic
role of paraoxonase is to prevent LDL oxidation with its attendant atherogenic effects,
the reported interactions may be relevant to the development of atherosclerosis in SLE. |
