level of tissue inhibitor of metalloproteinase -1 and urinary pyridinoline
between patients with generalized osteoaribritis and normal subjects, to
investigate whether the degree of joint involvement is related to those
measurements.
Methods: Twenty Eight females suffering^if generalized OA and 10
apparently healthy matched females as controls tuere' studied. Serum
MMP-3, plasma T1MP-I and urinary pyridinoline were measured. The
knee and hand joints were graded clinically (Steinbrocker) and radiologically
(Keligren and Lawrence).
Results: Serum level of MMP-3, plasma level ofTIMP-I and urinary py
ridinoline were significantly higher in generalized OA patients than nor
mal controls. The joint space width decreased with increasing Keligren -
Lawrence grade. All biochemical markers had negative correlations with
the joint space width, but only urinary pyridinoline had a significant cor
relation. AH biochemical markers had positive correlations with Stein
brocker grading.
Conclusion: the biochemical markers of bone metabolism are pro
posed as indicatoros of disease progress ofOA and altered bone turnover
might be a diagnostic or therapeutic target in patients with progressive
OA. |
