ABSTRACT
This study was done to evaluate and compare the toxic
potentialities of fluoxetine and Amitriptyline on cardiomyocytes of
albino rats. 30 male albino rats weighing 200-250 grams were divided
into 3 groups:
• Group (1) : Received fluoxetine once daily at dose of 45mg/kg
b.w for one month.
• Group (2) : Received Amitriptyline once daily at dose of 38
mg/kg b.w for one month.
• Group (3) : (Control) received distilled water once daily for the
same period.
Histochemically : Fluoxetine-treated group showed slight
decrease of ATPase and succinic dehydrogenase activities of cardiac
muscle while Amitriptyline caused marked decrease of ATPase and
succinic dehydrogenase activities.
Ultrastructural examination : Showed that fluoxetine caused
significant mitochondrial damage in atrial cardiomyocytes while
Amitriptyline caused significant severe mitochondrial damage in
atrial and ventricular cardiomyocytes. |
