ABSTRACT
Cadmium (Cd) is an important natural heavy metal which has no
biological function in man and is not normally found in body fluids and tissues.
It can produce acute and chronic poisoning in man and animals, leading to
bony lesions, liver damage and others. The present work aimed to follow up the
histopathological and histochemical changes in the liver (being the site of
detoxification) due to injection of:high doses of Cdc12 in mice (chronic toxicity).
Furthermore, the recovery signs from the possible toxic effects of this heavy
metal have been studied after its withdrawal. A total number of 36 adult male
mice were used in this study. They were divided into 2 main groups (control
&experimental). The control group (12 mice): injected by equivalent volumes
of saline solution (MO). The experimental group (24 mice): subdivided into 2
equal subgroups (A &B). Mice of subgroup (A) were injected S.C. every other
day with a dose of 1/8 LD50 for 45 days, whereas those of subgroup (B) where
given the double dose of Cdc12 (1/4 LD50) for the same period. Then, 9 mice of
each of the control group, subgroups (A & B) were sacrificed at 20, 30 & 45
days of injection (3 mice every time). Blood samples were taken at the end of
injection to study the liver functional tests. The remaining 3 mice of each of the
above were left for another 30 days without injection, then sacrificed to study
the recovery signs which might occur due to Cdc12 withdrawal. Small pieces of
the liver were taken every time and prepared for histological and
histochemical studies. Results : A) Liver function tests: significant elevation
- |
