ABSTRACT
Twenty —four adult male albino rats were utilized to study the effect of
acute noise stress on the cerebellum for short and long durations. The study
revealed that mild degree of subpial congestion and histological alterations
were observed in the cerebellum after one week of exposure to noise stress.
Also these changes were temporary and disappeared after one week of rest
following exposure.
However, numerous and significant neuro-histopathological and
cytological alterations were observed after three weeks of exposure to acute
noise stress. These changes included congestion of pial blood vessels in
addition to edema and inflammatory cell infiltration in tissue spaces.
Moreover, Purkinje cells revealed signs of degeneration and karyolysis, with
proliferation of numerous astrocytic cells. No significant signs toward
complete recovery were observed after an equal duration of rest following
noise exposure in the different cerebellar layers as compared with the
previously examined group.
Thus, it is clear that acute exposure to noise stress for a long duration
affects directly and irreversibly the neurons of cerebellum and causes
permanent histopathological changes. However, the short duration of exposure
insignificantly affects the neurons and causes temporary and reversible
histological alterations. |
