Hyperlipidemia. thrombophilia and hyperhomocysteinemia
were all known metabolic risk factors for coronary heart
disease. The association between the extra-gastric effects of chronic
helicobacter pylori (h.pylori) infection arid these risk factors in
dyspeptic patients needs to be clarified. Forty subjects were studied
for determination of serum total cholesterol, triglycerides, very low
density lipoprotein-cholesterol (VLDL-c), low density lipoproteincholesterol
(LDL-c), high density lipoprotein-cholesterol (HDL-c),
plasma clotting factors VII, X. XII activities, fibrinogen concentration,
antithrombin III (ATIII) activity as well as plasma total homocysteine.
They were 26 males and 14 females. Their age ranged from 31 to 41,
with a mean value of 35.8±2.6 years. They were categorized
according to the concentration of h.pylori antibodies (IgG) into 15
patients who were seronegative and another 15 patients who were
seropositive. These patients were compared with 10 healthy subjects,
age and sex matched who served as controls. The results of the present
work showed that; serum lipid profile had no significant differences in
seronegative and seropositive patients for h.pylori infection compared
with the control group (p>0.05). Moreover, plasma clotting factors
VII, X, XII had no significant changes while plasma fibrinogen
concentration and total homocysteine were significantly higher in
seropositive compared with both seronegative patients and the control
group (p<0.05). Additionally. seropositivity correlated significantly
with plasma fibrinogen concentration (r=0.76 ; p<0.05).
It could be concluded that, alteration of plasma fibrinogen and total
homocysteine might be considered metabolic risk factors for coronary
heart disease in dyspeptic patients due to Chronic h.pylori infection. |
