Obesity, hypertension, diabetes mellitus and smoking are all well
known risk factors for cardiovascular disease. However, the link between
these risk factors, plasma insulin and endothelin-1 (ET-1) as well
as cardiovascular diseases remains to be undetermined and must be
clarified So, the current work was carried on 120 men. Their ages ranged
between 32-64 years with a mean value 59±9.5, They were classified
into 6 groups ;control, obese, hypertensive, uncontrolled, controlled diabetics
and smokers. The results of this work showed that plasma Cpeptide
and insulin were significantly increased in obese, uncontrolled
and controlled diabetic groups (p<0.05) compared with the control
group. Moreover, plasma insulin was significantly increased in, hypertensive
group compared with the control group
(p<0.005) .In addition, plasma ET-1 was significantly increased in all
risky groups compared with the control group (p<0.05). Comparative
study of controlled versus uncontrolled diabetic group, plasma C-peptide,
insulin and ET-1 were all significantly decreased(P1<0.05).0n the otherhand
, correlation study showed that; plasma insulin was significantly
positive correlated with plasma ET-I in obese (r=0. 514 p< a 05), hypertensive
(r=0. 555 p<0.05), uncontrolled diabetes mellitus (r=0. 510 p<0.05)
and controlled diabetes mellitus groups (r= 0,496 p<0.05) while nonsignificantly
positive correlated with ET-1 in smoking group.
We could conclude that, hyperinsulinemia a a sign a danger signal for
the increase of plasma ET-1 and subsequent endothelial dysfunction in
Zohdy Mahdy et al
all risky subjects. So, they are more prone to ischemic heart disease.
However, further study was needed using ET-] antagonists on its receptors
which may be of help to abolish or at least to minimize its pathophysiological
effects on blood vessels. This is may be benefit for clinical intervention |
