Lipid profile, serum total cholesterol (T. C)., triglycerides(T.G). very
low density lipoproteins cholesterol (VLDLc)., low density lipoproteins
cholesterol (LDLc), high density lipoproteins cholesterol (HDLc) and
HDLc / LDLc ratio, liver and kidney functions, y-globulin were estimated
in 37 male rats that were included into 3 groups: control group (10), 12
rat were taken normal dose Nigella sativa (40 mg/kg/day for ten days), 15
rat were taken overdose Nigella (ten times normal dose for ten days). In
normal dose group, there was significant decrease (P < 0.02) in lipid
profile except HDLc and HDLc/ LDLc ratio where significant increase
(P <0.001) than control group was noticed. In overdose group, there was
significant (P <0.01) increase in T.C. and HDLc than control group.
Moreover, there was significant increase in lipid profile (P < 0.001) than
normal dose group. As regard liver, kidney functions and y-globulin, in
normal dose Nigella sativa there were significant (P < 0.05) decrease in
serum bilirubin and serum aspartate transaminase (ASP but, significant
(P <0.05) increase in y-globulin. Finally, we concluded tnat Nigella sativa
in normal dose and overdose had a very important beneficial effect on
lipid profile, liver, kidney functions and immunity. |
