Hepatocyte growth factor has been shown to be a potent stimulator
of DNA synthesis in a wide variety of cell types. The aim of this study
was to measure human hepatocyte growth factor (hHGF) in 45 patients
with chronic liver diseases and 20 healthy control, using enzyme linked
immunosorbent assay kit. Mean values of serum hHGF in normal control.
chronic hepatitis (CH), cirrhosis and schistosomiasis groups were
0.65±0.09, 1.76 ± 0.28, 3.9 ± 1.7 and 1.I0 + 0.27 ndiml respectively.
Serum hHGF in these diseases was significantly increased compared to
the controls, also the differences were significant among the different
disease groups. The levels in schistosomal group were significantly lower
than those in other chronic liver diseases while the levels in cirrhotic
group were found to be the highest. The levels of liFIGF showed a
positive correlation with total and conjugated bilirubin, asparate and
alanine aminotransferases and a negative correlation with total proteins
and prothrombin activity. These results suggest that serum levels of
hHGF vary in liver diseases reflecting liver damage and/or dysfunction. |
