02-free radicals play a major role in the pathogenesis of many
inflammatory conditions and malignancy. Also, sialic acid (Total &
Lipid-Bound) were recorded to be disturbed in inflammation and
malignancy. So, the aim of this work is to study the relationship
between 02-free radicals, lipid-bound sialic acid (LSA), total sialic
acid (TSA) and carcino-embryonic anitgen (CEA) in patients with
chronic bronchitis & bronchogenic carcinoma. Also, to evaluate LSA
TSA as Tumor markers in patients with bronchogenic carcinoma
and assessed the individual and combined values of LSA, TSA, &
CEA determination in these patients.
To clarify this isssue, two groups of patients were studied. The
first group included 20 patients with chronic bronchitis. Their age
ranged from (44-58) years. The second group included another 20
patients with bronchogenic carcinoma. Their age ranged from (45-62).
These groups of patients were compared with 10 healthy, age and sex
matched as controls.
The results of this study showed that; patients with chronic
bronchitis and bronchogenic carcinoma have a significant increase of
serum lipid peroxides (LP), LSA and TSA (P<0.00I) while serum
CEA is significantly increased only in patients with bronchogenic
carcinoma compared with the control group (P<0.001). Also, there
was a significant positive correlation between serum LP and LSA
(P<0.01), TSA (P<0.001) in patients with chronic bronchitis while,
there was non-significant positive correlation with serum CEA. Also,
there was a significant positive correlation between serum LP and
LSA (P<0.001), TSA (P<0.001) and CEA (P<0.05) in patients
with bronchogenic carcinoma. Serum LSA is more sensitive
biochemical marker (80%) than TSA (75%) and serum CEA
(60%) while serum CEA is more specific marker (73.3%) in diagnosis of patients with bronchogenic carcinoma than serum LSA
(46.7%) and TSA (33.3%).
We could conclude that, the increase of 02- free radicals may
be the trigger for the increase of serum level of cell surface related
sialoglycoprotein, sialoglycolipids, and tumor antigen (CEA). Neither
one of the three biomarkers success to be absolutely diagnostic nor
pathognomonic for bronchogenic carcinoma but, the combined
measurement of LSA and CEA in serum may be helpful for better
detection potential of bronchogenic carcinoma than either of the two
markers alone So, we recommend to interpretate the results carefully
in these group of patients to assure that inflammation or other benign
conditions are not causing changes in the test values. |
