To shed more Light on the relationship between ischemic heart disease
and iron, serum iron parameters (iron. ferritin and transferrin) were estimated
in fifty ischemic heart patients (15 stable angina, 15 crescendo angina
and 20 acute Myocardial Infarction, MI). Their ages ranged 43 - 58
years. Ten healthy subjects, matched with patients for age and sat
served as control group. Echocardiographic studies (ejection fraction (EF)
and end systolic volume (ESV) together with peak serum creatine phosphokinase
(CPK) were done for each case of infarction to correints, these
variables with the corresponding serum iron parameters.
Compared to controls, ischemic heart patients had highly significan:
increase of serum iron (103.5 + 25.6 vs 79.6 + 19.2, p<0.01) and serum
ferritin (94.7± 54.2 vs 44.4± 11.0, p<0.01) whereas they showed insignificant
increase of serum transferrin (273.8 + 83.8 vs 244.1 + 56.4.
p>0.05). Subgroup analysis showed that there was statistically significant
increase in serum iron and ferritin but not transferrin in patients
with stable and unstable angina while in cases with acute Ml. there was
signcant increase in all serum iron parameters. Correlation studies
showed that serum iron and ferritin but not transferrin were strongly correlated
with peak CPK EF and ESV. Patients with acute MI who hnti
complicated in-hospital course showed significant higher value of serum
iron. ferritin, transferrin, CPK and ESV but they had a significant lower
EF than non-complicated cases. In conclusion, serum iron and fen-WTI were sigrufficantly higher in ischemia
heart patients while serum transferrin was significantly higher
only in patients with acute ML In the infarction group, the higher the serum
iron and ferritin, the larger is the size of infarction, the worser is the
in-hospital course and the more Unpaired is the systolic function_ Thus,
the present study might give a new meaning for the emerging role of iron
in ischemic heart disease. |
