The objective of the current study was to determine
whether homocysteine elevations precede the development
of pre-eclampsia, and to examine the relationship between
the occurrence of pre-eclampsia and the degree of
hyperhornocysteinemia, so as to find a new prognostic
parameter for women with liable to develop preeclampsia.
The study comprised 103 pregnant females chosen of those
attending the Antenatal Care Unit at Benha University
Hospital and accepted to donate blood samples at the le
week of gestation. Women, who delivered at Benha
University Hospital. were retrospectively allocated into
two groups: Control group (Group C): comprised 64
(71.1%) parturient, who completed their full term
pregnancy without the development of pre-eclampsia. Preeclampsia
group (Group PEc): comprised 26 (28.9%)
parturient who developed pre-eclampsia throughout their
course of pregnancy, but had completed their full term
pregnancy.
Through the present study, estimated fasting plasma tHcys
levels were higher than the 90th percentile of the control
group ng/d1) in 6 (9.4%) women in group C and in 9
(34.6%) in group PEc. There was a significant (P<0.05)
increase of fasting plasma :Heys levels in nullipara preeclamptic
parturient as compared to multiparous control
parturient. Also, a negative significant correlation was
reported between parity and the fasting plasma tHcys level
in pre-eclamptic parturient. The present results showed a
significant increase of fasting plasma tHcys level in obese
women with a positive significant correlation between
fasting plasma tHcys level and BMI in PEc group. Thus, it
can be concluded that hyperhomocysteinemia is an
indirect risk factor for placental vasculopathy predating
clinical pre-eclampsia, and can be used as a biomarker for
identifring women at risk of complications and adverse
pregnancy outcomes. |
