To compare the efficacy and safety of topical 2.0% dorzolamide hydrochloride,
topical 0.5% levoburtolol and oral acetazolarnicle in preventing intraocular
pressure (10P) rise following neodymium: YAG (Ncb YAG) laser
posterior capsulotomy.
Forty eyes of forty patients were enrolled in this prospective, random-
:zed, placebo-controlled study. Pretreatment with dorzolamide, levobunclot,
acetazolamide or placebo was given 1 hour before capsulotomy. The
dose of treatment was 1 drop (approx. 20 p L) for any of the topical eye
drops (i.e. dorzolamide, levobunolol or placebo) and a single dose of 125
mg acetozolamicle.
At first and third hour postoperatively, 10Ps and 10P change from
baseline were significantly (P < 0.001) higher in the placebo group than in
any of the treated groups. No patient treated with dorzolamtde, levobuno-
Lot or acetozolcunide experienced an 10P higher than 30 mmFlg after capsulotomy,
but 60% of patients receiving placebo had an 1013 above this
level (P < 0.001). No serious side effects were recorded in any of the studied
patients. |
