Thirty two pseudophakic eyes of 32 patients undergoing Neodymium-
YAG laser posterior capsulotomy (YPC) were randomly assigned to receive
either dorzolamicle hydrochloride eye drops 2% (group A) or normal saline
(group B) one hour before and one hour after laser procedure then every 8
hours for 24 hours.
At /,2,3, and 24 hours after YPC, the mean changes in intraocular
pressure (TOP) from base line in dorzolamide treated eyes (+0. 6, +0.8,
+1.5 &-1.3 mmHg), were significantly less than saline treated eyes (+3.7,
+6.6, +8.9& +2.6 mmHg). The maximum rise in intraocular pressure (TOP)
was observed in both groups 3 hours after YPC. A rise of 5mm Hg or more
was recorded in 12.5% of eyes of group A versus 62.5% in eyes of group B
(P< 0.0001) while a rise of 10mrn Hg or more was not observed in eyes of
group A versus 37.5% in eyes of group B < 0.001).
It was found that prophylactic treatment with dorwlamide hydrochloride
eye drops 2% was significantly effective in preventing marked MP elevations
following YAG laser posterior capsulotomy. |
