Publications of Faculty of Medicine:CORRELATIVE STUDY OF ULTRASONOGRAPHIC FEATURES WITH CLINICAL MEASURES IN JUVENILE RHEUMATOID ARTHRITIS: Abstract

Title:
CORRELATIVE STUDY OF ULTRASONOGRAPHIC FEATURES WITH CLINICAL MEASURES IN JUVENILE RHEUMATOID ARTHRITIS
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Abstract:

JRA is the most common rheumatic disease in childhood Clinical evaluation of the disease is frequently supplemented with radiological investigations. Musculoskeletal ultrasonography has considerable advantages over other imaging methods in the diagnosis of JRA The aim of this work was to study the ultrasonographic features of the knee and hip joints in relation to clinical measures of the JRA and their relation to joint activity. Patients and methods: This study included 45 patients (age ranged 4 — 12 Y) as well as 20 apparently healthy children as a control group. All patients were subjected to full history, locomotor examination, knee and hip uhrasonography according to standard protocol Knee synovial thickness, suprapatellar effusion and hip synovial joint space (5.15) were measured. Results: Filly two knees out of 90 knees and 18 hips out of 90 hips examined were clinically active,. Knee synovial thickness had sensitivity 82.5% and specificity 95% while hip SJS had sensitivity 32.5% and specificity 85% in the diagnosis of joint activity in JRA patients. There is significant increase in fluid volume in suprapatellar bursa in active than in inactive knees. Conclusion: Ultrasonography detected parameters represent a reliable index of JRA disease activity with a higher sensitivity to ultrasonographic knee synovial thickness and a higher specificity for ultrasonographic knee effusion. This was not much realized with the hip SJS width. Introduction: Juvenile Rheumatoid arthritis (JRA) is a special form of rheumatoid arthritis which occurs in childhood and adolescence before the age of sixteen. It is considered a major cause of disability.( I ) It is primarily affects the joints but can also cause heavy damage to organs and systems. (2) History and physical examination supplemented with radiological investigation are the usual tools to reach a diagnosis in JRA. (3). Although previous studies in patients with JRA have demonstrated that MRI reveals early joint involvement, it considered expensive, lime consuming and subsequently not suitable as monitoring follow up method (4) Ultrasonography is an increasingly used technique for the evaluation of inflammatory joint disease (5.). It has been shown to be sensitive in the detection of synovitis and bone erosion in both small and large joints. (6) It has several advantages over MRI including cost, immediate availability in the clinic and the ability to scan multiple joints at the same time. (7) The aim of this paper was to study the ultrasonographic features of the knee and hip joints as a model of superficial and deep synovial joints in relation to the clinical measures of the JRA patients and also to evaluate the accuracy of ultrasound in diagnosis of local joint activity. Patients and Methods Forty five patients with JRA defined according to Cassidy1989 (8) classification criteria are referred from pediatric department to rheumatology and rehabilitation department in Benha University Hospital. 483