Background: Oxidative stress plays a
major role in the biochemical and
pathological changes associated with
myocardial infarction. The need to
identify agents with a potential for
preventing such damage has assumed
greet importance. In the present study,
the effect of oral administration of
green tea extract on oxidative stress
induced by experimental myocardial
infarction in rats was investigated.
Materials and Methods: Green tea
extracts (5 and10 mg/kg once daily)
was administered orally as pretreatment
for 14 days in adrenaline treated
rats.
Results: Oxidative stress induced cellular
damage as indicated by
ultrastructural changes, like disruption
of myofdament and z-band architecture
along with myocardial changes
was less.
Conclusion: We concluded that green
tea extract (GTE) afforded
cardioprotection by t-educing oxidative
stress induced in experimental infarction
of catecholamine assault. |
