hyperthyroidism and the possible
effects of vitamin E on these
changes.
The animals were designated as
control group (group I), 3, 3', 5-
Trtiodo —Thyronin (T3) injected group
(group II) and T3+ vitamin E injected
group (group III). At the end of the
study, tissue specimens were examined
for changes in structure in the T3
injected group, dilatation in sinusoids
and pale cytoplasm were observed, as
well as increased Kupffer cells and an
increased amount of glycogen. In T3
+vitamin E injected group the amount
of glycogen was similar to the control
.On electron microscopic examination
the mitochondria of T3 injected
group were slightly larger than those
of the control group. In T3 +vitamin E
injected group enlargement in the
spaces of Disse, increased lipid vacuoles
of Ito cells and increased microvilli
of hepatocytes were observed.
The results of this study indicate
that T3 injection causes structural
changes in the liver, and vitamin E has a slight protective effect on the liver of
rats with hyperthyroid. |
