chlorpyrifos (an organophosphate pesticide)
on Clara cells of rat.
• Chlorpyrifos was given orally by
gavage to rats at dose levels of (7.5 and
12.5 mg/kg b.w./day) for 30 days. The
toxic alterations in Clara cell histology
were evaluated using light and electron
microscope.
Clara cells showed cytoplasmic
vacuolization, SER swelling and formation
of cytoplasmic apical blebs.
Conclusion: We concluded that
• chlorpyrifos causes severe injury to
rat non ciliated bronchiolar (Clara)
epithelial cells. Generally the degrees
▪ of observed variations were found to
be dose dependent. It could be recommended
that the use of organophosphate
must be controlled to avoid any
hazards to the livings especially humans. |
