Changes in sex hormonal levels were studied in Schistosoma mansoni
infected and praziquantel treated mice (4.00 x 2 mg/Kg), drug control and in
normal control groups. It was observed that schistosomiasis lead to increase in
the level of testosterone, progesterone and I7B - esteradiol, 60 and 70 days postinfection
in male and female mice, respectively. In praziquantel treated group the
level of testosterone was lowered 10, 20 & 30 days post treatment, progesterone
and 17 13-estradiol fell 30 days post treatment after primary rise. The mechanism
of recorded changes will be discussed in details. |
