Tissue from non-infected eruption offifty AD
subjects, non-lesional skin of 10 patients and
from nonnal skin of 10 healthy persons was
subjected to direct inununofluorescence technique
using fluorescein isothiocyanate Labelled
antiserum specific for IgE and indirect
immunofluorescence technique using monoclonal
antibodies, IgE was detected in the lesional
skin of 88% of cases in both epidermis
and dermis. T-helper cells were present in all
biopsies from lesional skin while T-suppressor
cells were present in fewer num-ber of
biopsies. Langerhans cells (LCs) were found
in all biopsies from lesional skin of AD
patients.
This study suggests that IgE mediated type IV
hypersensitivity may be implicated in the aetiology
of atopic dermatitis. |
